Why is sublingual enteral?

Sublingual (under the tongue) or buccal (between gum and cheek) administration is advantageous for drugs that have low oral availability because venous drainage from the mouth bypasses the liver. Drugs must be lipophilic and are absorbed rapidly.

Enteral administration involves the esophagus, stomach, and small and large intestines (i.e., the gastrointestinal tract). Methods of administration include oral, sublingual (Dissolving the drug under the tongue), and rectal.

1) Sublingual medications

Administration through direct absorption into the mouth provides an advantage to medications you swallow. Sublingual drugs go into effect more quickly because They don’t have to go through your stomach and digestive system before being absorbed into the bloodstream.

Enteral Administration. Oral (PO) administration is the most frequently used route of administration because of its Simplicity and convenience, which improve patient compliance. Bioavailability of drugs administered orally varies greatly.

Enteral nutrition is administered through a feeding tube placed into the stomach or intestines. Parenteral nutrition is administered through a traditional intravenous (IV) line or via a central IV surgically placed during an outpatient procedure.

Sublingual. Sublingual administration can be classified into Parenteral as well, it does not enter the lower GastroIntestinal Tract, however it is placed under the tongue thus going oral. The drug diffuses into the capillary network and enters the system circulation directly.

By Drugs.com

Subutex is readily absorbed into your bloodstream through the gastrointestinal and mucosal membranes. But because of what scientists call “first-pass metabolism,” if you swallow Subutex instead of letting it dissolve under your tongue, Only a very small amount of the medicine will be absorbed.

Sublingual administration involves Placing a drug under your tongue to dissolve and absorb into your blood through the tissue there. Buccal administration involves placing a drug between your gums and cheek, where it also dissolves and is absorbed into your blood.

Sublingual administration of drug refers to the placement of drug under the tongue (Rehfeld et al., 2017). The sublingual route bypasses the first-pass metabolism and hence facilitates rapid absorption of the drug into the systemic circulation. Drug directly reaches the systemic circulation using blood vessels.

Enteral nutrition refers to Any method of feeding that uses the gastrointestinal (GI) tract to deliver nutrition and calories. It can include a normal oral diet, the use of liquid supplements or delivery by use of a tube (tube feeding).

Oral route

However, it has limitations Because of the way a drug typically moves through the digestive tract. For drugs administered orally, absorption may begin in the mouth and stomach. However, most drugs are usually absorbed from the small intestine.

Oral Routes of Medication Administration

• The oral route of medication administration is simple, convenient and the most common route.
• This route is easy to administer.
• Also, most patients tend to prefer the oral route of administration.
• Oral medications usually have a slower onset than other routes of administration.

“The goal of Enteral nutrition is to use the gastrointestinal [GI] tract if and whenever possible. Parenteral nutrition therapy uses intravenous feedings when the GI tract is not usable—for example, short term after GI surgery such as a bowel resection with prolonged recovery or complications.”

Enteral feedings Deliver nourishment through a tube directly into the GI tract. They’re ordered for patients with a functioning GI tract who can’t ingest enough nutrition orally to meet their needs. The feeding tube may stay in place as briefly as a few days or permanently, until the patient’s death.

The fastest route of absorption is Inhalation. Absorption is a primary focus in drug development and medicinal chemistry, since a drug must be absorbed before any medicinal effects can take place.

The oral route is considered as the first choice of route of drug administration as it is most convenient, cheap and usually a safe method of drug administration. The orally administered medicines are mostly absorbed in the small intestine, and to some extent in the stomach.

Several types of tubes are used for enteral feeding:

• Nasogastric tubes. …
• Nasojejunal tube (NJT) …
• Jejunostomy tubes (JEJ, PEJ or RIJ tubes) …
• Radiologically inserted gastrostomy tube (RIG) …
• Percutaneous endoscopic gastrostomy tubes (PEG tube)

Four major types of enteral nutrition formulas exist includ- ing: Elemental and semi-elemental, standard or polymeric, disease-specific and immune-enhancing.

Enteral administration involves Absorption of the drug via the GI tract And includes oral, gastric or duodenal (e.g., feeding tube), and rectal administration ▪

For a number of reasons some tablets shouldn’t be crushed or chewed. Most importantly, doing so May result in dose dumping; this is when the body very quickly absorbs a large amount of a drug. One consequence of dose dumping is an overdose of the drug, which can lead to death.

Sublingual Supplements

Substances absorbed under the tongue get into the bloodstream without having to go through the gastrointestinal tract. You’re not supposed to swallow while a B-12 tablet is dissolving under your tongue, otherwise the vitamin ends up in your stomach and defeats the purpose.

The active ingredient in Subutex is buprenorphine. It is administered as a tablet that you dissolve under your tongue, and It should never be chewed or swallowed. Even talking while the tablet is dissolving can lower the amount of medicine absorbed.

Medical Definition of sublingual

(Entry 1 of 2) 1 : Situated or administered under the tongue Sublingual tablets. 2 : of or relating to the sublingual glands.

Wait at least 2 minutes before swallowing to make sure all the drug is absorbed. The dosage is based on your medical condition, age, and response to treatment. If directed by your doctor, use this medication regularly in order to get the most benefit from it. To help you remember, use it at the same time(s) each day.

Sublingual Administration

• Immunotherapy.
• Buprenorphine.
• Antigen.
• Allergen.
• Opiate.
• Glyceryl Trinitrate.
• Nifedipine.